Lecturer in EUSES – Center affiliated with the UdG. PhD in Biochemistry and Molecular Biology. Graduate in Biochemistry and Molecular Biology.
Last years she works as a post-doctoral researcher in the neurosciences field. She started her scientific career in the Biochemical Psychopharmacology research group (UAB) studying drug addiction, specially how cocaine intake can alter the expression of the H3 receptor and how the modulation of the histamine H3 receptor can influence the cocaine self-administration behavior in rats. Then, she moved to the research group of Neurobiology of Behavior (UPF) and focused her studies in the pain-depression dyad and how chronic neuropathic pain-induced mood disorders can lead to an increased alcohol intake in mice. Currently, she belongs to the Neurodegenerative Diseases research group (VHIR) and investigates the involvement of neuromelanin in the degeneration of dopaminergic neurons during Parkinson’s disease. She developed and validated a UPLC-MS/MS method to monitor possible alterations in neurotransmitter and o-quinone levels that can be applied to in vitro and in vivo experimental models of neurological disorders and human brain samples. In fact, this methodology is currently applied to the research project: “Modulation of age-dependent neuromelanin accumulation as a novel therapeutic strategy for Parkinson’s disease and brain aging”.
Her research was published in specialized journals, as listed below:
Gonzalez-Sepulveda, M., Laguna A., Carballo-Carbajal I., … , Vila M (1/14); Validation of a reversed phase UPLC- MS/MS method to determine dopamine metabolites and oxidation intermediates in neuronal differentiated SH-SY5Y cells and brain tissue. ACS Chem. Neurosci. 2020;11(17):2679-2687.
Carballo-Carbajal I*, Laguna A*, …, Gonzalez-Sepulveda M, …, Vila M (8/16) Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis. Nature Communications 2019, 10 (1), 973).
Marcos J, Renau N, Valverde O., …, González-Sepúlveda, M., … , Pozo OJ. (6/10) Targeting Tryptophan and Tyrosine Metabolism by Liquid Chromatography Tandem Mass Spectrometry. Journal of Chromatography A 2016 1434:91-101
Marta González-Sepúlveda, Oscar J Pozo, Josep Marcos, Olga Valverde. Chronic pain causes a persistent anxiety state leading to increased ethanol intake in CD1 mice. Journal of Psychopharmacology 2016, 30(2):188-203.
She also has worked as associate professor in the Pompeu Fabra University. She has participated in some subjects of the Degree in Human Biology and two masters of the Experimental and Health Sciences Department. Moreover, she has coordinated different subjects and supervised many final degree projects of the Degree in Criminology and Public Prevention Policies of the Law Department.
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